Protective effects of a cystine and theanine mixture against acute radiation injury in rats.
RatRadiationWistarMale280 mg/kgPre-treatment for 5 days before irradiation
Model: Whole-body irradiation at 5 Gy, with assessment of acute injury to the small intestine (jejunum) and bone marrow
Pre-treatment significantly improved weight loss and survival after 5 Gy compared with control. It increased mucosa and crypt length and mitotic and Ki-67 positive cells while reducing apoptotic, TUNEL and cleaved caspase-3 positive cells, and suppressed bone marrow cell loss and apoptosis.
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