Immunization with anti-Tn immunogen in maternal rats protects against hyperoxia-induced kidney injury in newborn offspring.
RatOtherSprague-DawleyFemale dams immunised; sex of pups not statedIntraperitoneal50 micrograms per doseMaternal immunisation before injury, at 8, 6, 4, 2 and 0 weeks before delivery
Model: Neonatal hyperoxia-induced kidney injury; pups reared for 2 weeks in room air or an 85 per cent oxygen-enriched atmosphere
Hyperoxia reduced body weight and caused tubular and glomerular injury with increased 8-hydroxy-2'-deoxyguanosine, NF-kappaB and collagen deposition. Maternal Tn immunisation reduced kidney injury and collagen deposition alongside lower 8-hydroxy-2'-deoxyguanosine and NF-kappaB expression.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.