Early delivery and prolonged treatment with nimodipine prevents the development of spasticity after spinal cord injury in mice.
MouseSpinal cord injuryUnspecifiedStarted in the acute phase after spinal cord injury
Model: Chronic spinal cord injury model in mice
Nimodipine started in the acute phase completely prevented development of spasticity, measured as increased muscle tone and spontaneous spasms. The inhibition of aberrant muscle activity persisted after treatment ended, and Cav1.3 was shown to mediate the effect.
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