Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity.
MouseRadiationWild-type and acid sphingomyelinase knockout (ASMKO) miceMale
Model: Total body or abdominal irradiation at 15 Gy inducing gastrointestinal syndrome; supported by primary endothelial cell and intestinal T84 cell co-culture and enteroid models
Blocking endothelial secretion of acid sphingomyelinase or ceramide, genetically, pharmacologically or immunologically, abolished radiosensitisation of intestinal epithelial cells; ASMKO mice did not show the serum ceramide rise and did not develop intestinal failure injury. Ceramide reduced entero…
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