Immediate or Delayed Transplantation of a Vein Conduit Filled with Nasal Olfactory Stem Cells Improves Locomotion and Axogenesis in Rats after a Peroneal Nerve Loss of Substance.
RatCrushPeripheral-nerve crushFischerFemale hosts; male donors for olfactory ecto-mesenchymal stem cellsn = Control n=8; immediate vein graft n=14; immediate vein graf…Direct injection into the vein conduit lumen1 million cells in 10 microlitres of thrombin and fibrinoge…Immediate (vein conduit at time of injury, cells at week 2) or delayed (vein co…
Model: Left common peroneal nerve 3 mm segment excised 5 mm distal to the sciatic trifurcation, bridged with a 1 cm autologous femoral vein conduit leaving a 3 mm gap
OEMSC improved locomotor recovery, partially preserved the fast contractile phenotype (maximal rate of relaxation improved in the delayed graft arm, p<0.05) and increased axon numbers in medial and distal nerve segments, with no benefit on muscle mass, G-ratio or metabosensitive afferent responses.…
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