Formoterol, a beta-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6MaleIntraperitoneal0.3 mg/kgFirst dose 15 min after controlled cortical impact
Model: Controlled cortical impact traumatic brain injury
Formoterol increased cortical mitochondrial DNA copy number and cortical and hippocampal respiration, raised hippocampal mitochondrial calcium buffering capacity, restored novel object recognition and Morris water maze performance, and increased hippocampal neuron numbers and white matter sparing,…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.