Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome.
RatChemical/toxinSprague-DawleyFemale (virgin)n = 48 rats, 12 per group across 4 groupsOralFrankincense 200 mg/kg plus myrrha 200 mg/kgDosing on days 1, 2 and 3, with experiments performed on day 4
Model: Cyclophosphamide-induced acute interstitial cystitis/painful bladder syndrome, 150 mg/kg intraperitoneally; supported by primary human urothelial cell assays
Frankincense and myrrha increased voiding interval and pain tolerance compared with the cyclophosphamide group (p<0.05) and increased bladder zonula occludens-2 expression, with low-dose extract increasing urothelial cell proliferation and migration in vitro.
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