Ribonuclease attenuates acute intestinal injury induced by intestinal ischemia reperfusion in mice.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6JMalen = 32 mice, 8 per group across 4 groupsThree doses given during the perioperative window
Model: Superior mesenteric artery clamped for 1 h followed by 2 h reperfusion
RNase treatment reduced inflammatory cytokine production, inhibited intestinal apoptosis and downregulated Toll-like receptor 3 expression after intestinal ischaemia-reperfusion, consistent with a causal role for raised extracellular RNA.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.