Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.

PMID 32265721 ↗2020Reported benefit

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.

MouseWoundNSG (immunodeficient)n = 7 mice per group at each of 2 time points, 2 implants per m…Subcutaneous implantation of the cell-seeded meshCell number not stated; cells applied to the mesh surface b…Concurrent with implantation

Model: Subcutaneous abdominal implantation model of foreign body response: 1.2 cm lower abdominal skin incision with blunt dissection to create bilateral pockets, one nanomesh implanted per pocket and sutured to the abdominal fascia

Endometrial mesenchymal stem cells suppressed acute pro-inflammatory gene expression at 1 week and, by 6 weeks, significantly upregulated about 35 genes spanning extracellular matrix, adhesion, angiogenesis and anti-inflammatory pathways, with more collagen deposited within the mesh, neovessels adj…

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Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.

Evidence by therapy association

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.