Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice.
MouseChemical/toxinC57BL/6 (green fluorescent protein donors)Direct orthotopic injection into the left lungImplantation before paraquat challenge (preventive design)
Model: Paraquat-induced severe acute lung injury
Survival was 39 percent in the foetal lung implantation group versus 5.9 percent in the vehicle group (p=0.034), with reduced inflammatory cells and oedema, increased proliferation of implanted foetal lung cells and significantly less airway septal thickening (p<0.001).
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.