Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis.
RatOtherSprague-DawleyMalen = n=10 per group, 4 groups, 40 rats totalOral gavage1 mL per 100 g body mass per doseFirst dose immediately after induction of severe acute pancreatitis
Model: Severe acute pancreatitis with secondary myocardial injury induced by retrograde injection of 5 percent sodium taurocholate 1 mL/kg into the distal pancreatic bile duct at 0.2 mL/min under pentobarbital anaesthesia
Qingyi decoction reduced 24 h mortality from 40 percent to 10 percent (p=0.0047), restored left ventricular ejection fraction and fractional shortening, reduced myocardial necrosis and inflammatory infiltration, lowered serum cytokines, reduced the apoptotic index from 38.8 plus or minus 2.7 percen…
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