Synthetic poly(vinyl alcohol)-chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility.
MixedHaemorrhage/shockUncontrolledSprague-Dawley rats; Bama miniature pigsTopical application to the woundApplied at the time of haemorrhage
Model: Femoral artery haemorrhage model in rats and pigs, and gunshot wound experiment representing noncompressible haemorrhage
PVA-CS sponges showed robust mechanical strength, rapid water-triggered swelling, improved blood clotting and platelet activation versus gauze and PVA, high cytocompatibility, and in vivo excellent haemostatic performance with enhanced wound healing, increased re-epithelialisation and decreased gra…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.