Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the NLRP3 Inflammasome.
MouseOtherC57BL/6 and transgenic miceMale and female
Model: Water immersion restraint stress-induced acute gastric lesions
GKN2 aggravated stress-induced gastric lesions and mucosal cell death in a gastric acid independent manner by recruiting neutrophils and driving inflammatory factor release through the NLRP3 inflammasome, so inhibiting GKN2 attenuated the lesions. Cortisol-activated NR3C1 acted as the upstream tran…
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