The intestinal injury caused by ischemia-reperfusion is attenuated by amniotic fluid stem cells via the release of tumor necrosis factor-stimulated gene 6 protein.
RatIschaemia-reperfusionIntestinal / mesentericSprague-DawleyIntravenousInjected intravenously upon reperfusion, that is immediately after the 90 minut…
Model: Superior mesenteric artery occlusion for 90 minutes followed by reperfusion, causing intestinal ischaemia-reperfusion injury; complemented by hypoxia-induced damage in intestinal organoids
AFSC migrated preferentially to the ileum via the circulation and reduced ileal injury, inflammation and oxidative stress at 48 hours. These effects depended on TSG-6 secretion, and recombinant TSG-6 alone protected intestinal organoids against hypoxia-induced epithelial damage and attenuated intes…
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