Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide-induced acute lung injury.
MouseEndotoxin/LPSBALB/cMalen = 10 mice per group, four groups (control, LPS model, PAF 500…Oral gavage500 mg/kgPretreatment; LPS was injected 1 hour after the last PAF dose
Model: Acute lung injury induced by a single intraperitoneal injection of lipopolysaccharide (5 mg/kg)
PAF at 500 mg/kg reduced lung histopathological damage and the lung wet/dry ratio, lowered cytokine release including TNF-alpha and accumulation of oxidation products, decreased NF-kappaB, p-p38, ERK, JNK, p53, caspase-3 and COX-2, enhanced nuclear Nrf2 translocation, corrected the energy metabolis…
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