Cardioprotective Effects of Latifolin Against Doxorubicin-Induced Cardiotoxicity by Macrophage Polarization in Mice.
MouseChemical/toxinC57BL/6Malen = 16 mice per group in four groups; n = 6 for LDH, n = 8 for…Oral, suspended in 0.5 per cent sodium carboxymethyl cellulose50 mg/kg or 100 mg/kg orally in vivo; 1.25, 2.5, 5 and 10 m…Oral latifolin started 4 days before the doxorubicin injection, which was given…
Model: Doxorubicin-induced cardiotoxicity, single intraperitoneal dose of doxorubicin 20 mg/kg on day 5
Latifolin at 100 mg/kg significantly reduced cardiac LDH, improved left ventricular ejection fraction and fractional shortening, and preserved myocardial architecture. It decreased myocardial iNOS and CD86 expression and increased CD206, IL-10 and IL-4R. In cultured peritoneal macrophages latifolin…
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