JMV5656, a short synthetic derivative of TLQP-21, alleviates acid-induced lung injury and fibrosis in mice.
MouseChemical/toxinC57BL/6 (from MeSH indexing: Mice, Inbred C57BL)MaleIntraperitoneal injection0.6 mg/kgPre-treatment on experimental days 1 and 2, with injury induced on day 3
Model: Unilateral acid aspiration acute lung injury, instillation of HCl (1.5 ml/kg of 0.1 M HCl in 0.9% NaCl) into the right lung under deep anaesthesia
JMV5656 significantly reduced polymorphonuclear cell recruitment into the alveolar space 24 h after acid instillation but had no effect on BAL cytokine levels. Two weeks after injury, static compliance of the right lung was significantly higher and acid-induced collagen deposition was blunted in JM…
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