The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice.
MouseChemical/toxinC57BL/6JMalen = Not reported per group; zero of 12 mice died in the cisplat…Trametinib intraperitoneal; U0126 route not statedU0126 5 mg/kg twice weekly (7.5 and 15 mg/kg twice weekly c…Started after tumour engraftment (day 10 for U0126, day 17 for trametinib) and…
Model: Cisplatin-induced acute kidney injury; low-dose model of cisplatin 12.5 mg/kg once weekly for 4 weeks in mice bearing subcutaneous CMT167 KRAS-mutant lung carcinoma flank tumours, plus a short-term model of cisplatin 30 mg/kg on day 0 with sacrifice on day 3
U0126 significantly improved kidney function, acute tubular necrosis and tubular apoptosis and also reduced tumour weight and volume. Trametinib did not protect against acute kidney injury in the 4 week model but decreased tumour growth more than cisplatin and prolonged survival in the high-dose mo…
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