5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Persisters Under Hypoionic Conditions.
MouseWoundICRMalen = n = 3 per group in vivoTopical application to the wound120 microlitres of 4 mM 5-methylindole plus 100 micrograms/…Applied immediately after bacterial seeding and absorption
Model: Acute full-thickness skin excision wound (1 cm by 1 cm) on the back, seeded with 5 microlitres of concentrated stationary-phase Staphylococcus aureus including MRSA and CCCP-induced persisters
Tobramycin in pure water killed bacteria more effectively than in saline in vivo (p = 0.011). Addition of 5-methylindole gave only a marginal further gain against stationary-phase cells in vivo but significantly enhanced killing of CCCP-induced persisters (p = 0.012).
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.