Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice.
MouseRadiationC57Bl/6, C3H, and TCF/Lef1-HIST1H2BB/EGFP Wnt reporter transgenics on C57Bl/6 backgroundMale and femalen = Crypt survival assay n = 5 mice per treatment group per dos…Subcutaneous18 mg/kg in 100% DMSO24 hours after irradiation
Model: X-ray total body irradiation (6.5 Gy C57Bl/6, 6 Gy C3H for survival; 4 Gy for progenitor recovery; 3 Gy for Wnt reporter) and sub-total body irradiation with head and forelimb shielding (13 or 14 Gy for crypt survival; 14 and 15.55 Gy for gastrointestinal survival), 320 kVp, 12.5 mA
SB216763 improved 30 day survival and progenitor regeneration after total body irradiation in male C57Bl/6 mice only. There was no benefit in females of either strain, no significant benefit in C3H, no additional benefit over G-CSF plus ciprofloxacin, and no effect on gastrointestinal acute radiati…
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