C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.

PMID 32174788 ↗2020Reported benefit

C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.

MouseTBIClosed-head / concussionC57BL/6n = Not stated for animal groups; in vitro n denotes independen…IntraperitonealPep1-E1A 2 mg/kg stated in Methods and 3 mg/kg stated in Re…Pep1-E1A at 1 hour and 24 hours after a single 0.8 J impact; MTOB and NSC95397…

Model: Closed-head mild traumatic brain injury using CHIMERA, pneumatically driven 50 g piston delivering 0.5, 0.65, 0.7 or 0.8 J to a 2.5 mm radius area around bregma; repeated mild injury model used two 0.5 J impacts 24 hours apart

CtBP target genes rose with impact energy and peaked at 24 hours. Pep1-E1A improved neurological severity score at 48 hours (p < 0.05) and suppressed target genes more in blood leukocytes (56 to 83%) than brain (21 to 41%). NSC95397 improved score at 48 and 72 hours and suppressed target genes by 6…

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C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.

Evidence by therapy association

C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment.