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PRECLINICAL PUBLICATION · 2020

An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-kappaB and neuronal cell death.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32173261 ↗2020Reported benefit

An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-kappaB and neuronal cell death.

RatSpinal cord injuryCompressionSprague-DawleyFemaleLocal injection of the copolymer system at the injury site

Model: Crush spinal cord injury

The MFG-E8-loaded copolymer decreased proinflammatory cytokine expression and neuron death, ameliorated inflammation, decreased fibrotic scar, promoted myelin regeneration and reduced overall injury severity.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.