An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-kappaB and neuronal cell death.
RatSpinal cord injuryCompressionSprague-DawleyFemaleLocal injection of the copolymer system at the injury site
Model: Crush spinal cord injury
The MFG-E8-loaded copolymer decreased proinflammatory cytokine expression and neuron death, ameliorated inflammation, decreased fibrotic scar, promoted myelin regeneration and reduced overall injury severity.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.