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PRECLINICAL PUBLICATION · 2020

CXCL16 silencing alleviates hepatic ischemia reperfusion injury during liver transplantation by inhibiting p38 phosphorylation.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32171552 ↗2020Reported benefit

CXCL16 silencing alleviates hepatic ischemia reperfusion injury during liver transplantation by inhibiting p38 phosphorylation.

MouseIschaemia-reperfusionHepaticC57BL/6

Model: Hepatic ischaemia-reperfusion injury during liver transplantation; in vitro oxygen-glucose deprivation and reoxygenation in AML12 hepatocytes

Silencing CXCL16 reduced CXCR6 expression, hepatocyte apoptosis and hepatic injury, and the protection was reversed by activation of p38 phosphorylation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.