Comparison of the Efficiency of Systemic and Local Cell Therapy with Human Umbilical Cord Blood Mononuclear Cells in Rats with Severe Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntravenous or intraspinal (intralesional)
Model: Severe contusion spinal cord injury
Both routes significantly improved recovery of hind limb motor function by 35 to 40% relative to self-recovery (p <= 0.05), with no significant difference between intravenous and intraspinal administration.
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