The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury.
MouseSpinal cord injuryComplete transectionC57BL/6 wild typeMalen = 139 animals in total; hMSC n = 40, HBSS n = 26, no-injectio…Intraparenchymal spinal cord injection between T10 and T11, 29G needle, 0.5 microlitres per minute5 x 10^5 hMSCs in 0.5 microlitres of HBSS; recombinant mous…hMSCs on postoperative day 1 (24 hours after injury); recombinant CCL5 on posto…
Model: Complete spinal cord transection between T9 and T10 with a thin-bladed razor under sevoflurane anaesthesia
hMSC transplantation improved locomotor score from day 3 to day 14, raised Ccl2 about 16-fold at day 3 and Ccl5 about 11-fold at day 14, suppressed Aif1, Elane and Mpo at day 3, and increased the alternatively activated macrophage markers Arg1 and Chil3 and the axonal regeneration markers Dpysl2 an…
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