Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice.
MouseSpinal cord injuryContusionC57BL6FemaleIntravenous by tail vein injectionBeginning 24 hours after injury
Model: Unilateral moderate contusion at the fifth cervical level
Treatment prevented the injury-induced rise in collagen type 1 alpha 1 and tenascin N and reduced microglial and macrophage recruitment. Functional recovery began around 2 weeks after injury and continued to improve, whereas controls recovered significantly less.
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