Pharmacological inhibition of lipid peroxidative damage by the 21-aminosteroid U-74389G improves cortical mitochondrial function following traumatic brain injury in young adult male rats.
RatTBIControlled cortical impactSprague-DawleyMalen = Not stated per group; degrees of freedom imply roughly 8 an…Intravenous then intraperitonealFour paradigms in mg/kg (intravenous plus intraperitoneal):…Intravenous at 15 minutes and 2 hours after injury, intraperitoneal booster at…
Model: Severe controlled cortical impact traumatic brain injury, 6 mm craniotomy, 5 mm beveled tip at 3.5 m/s or greater to a depth of 2.2 mm with dura intact
All respiration states were reduced at 72 hours in vehicle-treated injured rats. The 1 mg/kg intravenous plus 3 mg/kg intraperitoneal paradigm significantly improved states II, III, V(II) and the respiratory control ratio and reduced 4-hydroxynonenal and acrolein to near sham levels. Higher doses w…
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