Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 471 rats enrolled, 307 analysed, 164 excluded for death or…Intravenous1, 3 and 10 mg/kg in dose ranging, with 3 mg/kg selectedImmediately after monofilament withdrawal at reperfusion; a delayed cohort rece…
Model: Transient middle cerebral artery occlusion for 2 hours followed by reperfusion, intraluminal monofilament, chloral hydrate 400 mg/kg anaesthesia; a separate cohort had permanent occlusion without reperfusion
Ciclopirox olamine reduced infarct volume by 13.1%, 22.5% and 11.9% at 1, 3 and 10 mg/kg, improved neurological deficit and brain oedema, and improved rotarod performance with multiple dosing better than single dosing. It reduced neuronal loss, apoptosis, astrocyte activation, cytokines and blood b…
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