miR-182 prevented ototoxic deafness induced by co-administration of kanamycin and furosemide in rats.
RatChemical/toxinSprague-DawleyFemaleTrans-round window niche delivery to the cochleamiR-182 mimics delivered before intraperitoneal kanamycin and furosemide
Model: Ototoxic cochlear outer hair cell loss and permanent deafness induced by intraperitoneal kanamycin plus furosemide
Cochlear overexpression of miR-182 attenuated permanent auditory brainstem response threshold shifts and reduced loss of outer hair cells and stereocilia after kanamycin plus furosemide.
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