5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitoneal4 mg/kgChronic phase, 8 weeks after contusion; given 5 min before each daily intermitt…
Model: Midcervical spinal cord contusion, studied at 8 weeks post-injury
Tidal volume increased similarly in SB269970 and vehicle groups within 60 min after the first hypoxia session, but baseline tidal volume rose significantly in SB269970-treated rats after 2 to 3 days of daily treatment, indicating a transient improvement.
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