Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury.
RatIschaemia-reperfusionHepaticWistarMalen = Three groups of male Wistar rats (sham, ischaemia/reperfusi…Intraperitoneal10 mg/kg/dayPretreatment for 10 days before hepatic ischaemia/reperfusion
Model: Hepatic ischaemia/reperfusion with remote renal injury
Vildagliptin significantly improved the biochemical markers of remote renal injury and the histopathological changes after hepatic ischaemia/reperfusion, and blocked the upregulation of renal TGF-beta/Smad/alpha-SMA mRNA expression.
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