Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury.
MouseEndotoxin/LPSC57BL/6Male
Model: Lipopolysaccharide-induced acute lung injury
P12 alleviated lung inflammation and damage, reduced inflammatory cell infiltration and increased IL-10 in the lung. It primarily targeted lung macrophages, drove bone marrow-derived macrophages toward an M2 phenotype in vitro, increased alveolar M2 macrophages and reduced alveolar and interstitial…
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