11-Keto-beta-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus.
RatChemical/toxinSprague-DawleyIntraperitoneal10 or 50 mg/kg30 min before kainic acid injection
Model: Kainic acid-induced excitotoxic hippocampal injury (15 mg/kg intraperitoneally); hippocampal synaptosome glutamate release in vitro
11-Keto-beta-boswellic acid dose-dependently inhibited 4-aminopyridine-stimulated glutamate release in a calcium-dependent, vesicular manner, and pretreatment considerably ameliorated the kainic acid-induced rise in glutamate and CA3 neuronal death.
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