Role of oxidants, eicosanoids, and neutrophils in amphotericin B lung injury in rats.
RatChemical/toxinInbred strain not specifiedMaleAdded to the perfusate of isolated perfused lungsAmphotericin B 1 mg/kg; doses of the protective agents not…
Model: Acute lung injury induced by amphotericin B (1 mg/kg) in intact rats and in isolated lungs perfused with cell-free and plasma-free physiological solution
Amphotericin B produced neutrophil-independent acute lung injury with vasoconstriction and oxidant stress. Methylparaben, catalase, phenidone and CGP 35949B each attenuated the injury in isolated lungs, and methylparaben and CGP 35949B prevented the rise in lung leukotriene C4 and B4.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.