The role of CGRP receptor antagonist (CGRP8-37) and Endomorphin-1 combination therapy on neuropathic pain alleviation and expression of Sigma-1 receptors and antioxidants in rats.
RatSpinal cord injuryCompressionWistarMalen = 56 male Wistar rats divided into seven groups
Model: Spinal cord compression injury with neuropathic pain
Endomorphin-1 and CGRP8-37 each reduced neuropathic pain after spinal cord compression injury, but combination therapy produced no further reduction in pain threshold compared with either monotherapy. Sigma-1 receptor expression rose after all treatments, and combination therapy increased GPx and S…
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