Effect of oleanolic acid for prevention of acute lung injury and apoptosis.
RatChemical/toxinWistar albinoFemalen = 70 female Wistar albino rats in seven groups of 10
Model: Acute lung injury induced by intratracheal peroxynitrite injection, assessed at 24 and 48 h
Peroxynitrite raised inflammatory mediators and tissue injury scores relative to control. Oleanolic acid treatment significantly reduced these markers and tissue injury scores, with p<0.001 for TNF-alpha and apoptosis at 48 h.
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