Antibacterial Activity and Pharmacokinetic Profile of a Promising Antibacterial Agent: 22-(2-Amino-phenylsulfanyl)-22-Deoxypleuromutilin.
MouseWoundPharmacokinetics characterised after intravenous, intraperitoneal and oral administration
Model: Experimental methicillin-resistant Staphylococcus aureus wound infection model, with acute oral toxicity and pharmacokinetic studies
Amphenmulin enhanced wound closure and promoted healing, inhibited MRSA counts in the wound and decreased serum TNF-alpha, IL-6 and MCP-1. Acute oral toxicity testing gave a median lethal dose above 5000 mg/kg.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.