Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury.
RatSpinal cord injuryHemisection / partialInjection of the drug-loaded alginate hydrogel into the lesion siteInjected into the lesion site at the acute phase after injury
Model: Spinal cord hemisection
Dual-drug treatment reduced inflammation at 7 days, decreased scar tissue and increased neuronal regeneration at 28 days, and produced faster and sustained functional improvement compared with the other experimental groups.
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