Telocytes inhibited inflammatory factor expression and enhanced cell migration in LPS-induced skin wound healing models in vitro and in vivo.
Model: 6 mm full-thickness dorsal skin excisional wound made with scissors, with intradermal lipopolysaccharide (10 micrograms/mL in 0.2 mL PBS) to model excessive inflammation; parallel in vitro transwell co-culture of telocytes with HaCaT keratinocytes, human dermal microvascular endothelial cells or L929 fibroblasts under 1 microgram/mL lipopolysaccharide
Telocytes accumulated in the dermis of human chronic wound tissue. Lipopolysaccharide delayed wound healing on days 2 and 8, and telocyte injection significantly increased the healing rate versus lipopolysaccharide alone (n = 6) while reducing inflammatory cell infiltration. In vitro, telocytes rev…
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