Acute administration of perampanel, an AMPA receptor antagonist, reduces cognitive impairments after traumatic brain injury in rats.
RatTBIFluid percussionSprague-DawleyMaleGiven either before or after injury (acute administration)
Model: Lateral fluid percussion injury, producing both focal and diffuse traumatic brain injury
Pre-injury or post-injury perampanel attenuated the injury-induced rise in the pro-apoptotic bax to bcl-xL ratio in the hippocampus and reduced impairments in learning and memory and in reward-seeking behaviour. Only male rats were studied, so sex differences remain undetermined.
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