Blockage of Kv1.3 regulates macrophage migration in acute liver injury by targeting delta-catenin through RhoA signaling.
MouseEndotoxin/LPSC57BL/6MaleIntraperitoneal100 nM margatoxin (in vivo); 5-10 nM in RAW264.7 cell assays
Model: Acute liver injury induced by intraperitoneal lipopolysaccharide (3 ug/kg) plus D-galactosamine (200 mg/kg)
Margatoxin treatment attenuated acute liver injury, with reduced hepatic macrophage infiltration, less histological damage and lower serum ALT, AST and TNF-alpha. Transcriptomic analysis identified downregulation of delta-catenin, and delta-catenin overexpression or knockdown correspondingly increa…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.