Polyethylene Glycol 35 (PEG35) Protects against Inflammation in Experimental Acute Necrotizing Pancreatitis and Associated Lung Injury.
RatChemical/toxinWistarMaleIntravenous, via the penile vein10 mg/kgProphylactic administration before induction of acute necrotizing pancreatitis,…
Model: Acute necrotizing pancreatitis induced by retrograde infusion of 5% sodium taurocholate into the biliopancreatic duct, with associated lung injury assessed at 3 h
Prophylactic PEG35 reduced plasma lipase, local and systemic inflammatory mediator expression (IL-6, IL-1beta, TNF-alpha, CXCL2), adhesion molecule levels, neutrophil recruitment and cell death in both pancreas and lung. Therapeutic PEG35 significantly reduced associated lung injury even when the p…
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