Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury.
MouseIschaemia-reperfusionRenalC57BL/6MaleDirect injection into the renal cortexMacrophage suspension in 50 uL phosphate-buffered saline in…
Model: Renal ischaemia-reperfusion acute kidney injury produced by bilateral renal artery (pedicle) occlusion for 30 min followed by reperfusion
Peritoneal M2 macrophages alleviated renal injury and the inflammatory response after ischaemia-reperfusion injury and promoted proximal tubular epithelial cell proliferation both in vivo and in vitro, supporting M2 macrophage transplantation as a candidate cell therapy for acute kidney injury.
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