Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury.
MouseEndotoxin/LPSC57BL/6Male12.5, 25 and 50 mg/kg in vivo (dissolved in 5% dimethyl sul…1 h before lipopolysaccharide and D-galactosamine challenge
Model: Acute liver injury and acute liver failure induced by lipopolysaccharide (30 ug/kg) plus D-galactosamine (600 mg/kg)
Chicoric acid reduced serum AST and ALT and lowered mortality after lipopolysaccharide and D-galactosamine challenge. It suppressed MAPK and NF-kappaB signalling, activated the Nrf2 pathway with increased AMPK, raised hepatic glutathione and reduced reactive oxygen species and myeloperoxidase, and…
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