Topical transient receptor potential ankyrin 1 antagonist treatment attenuates nociception and inflammation in an ultraviolet B radiation-induced burn model in mice.
MouseBurnUnspecifiedMaleTopical (cutaneous)0.05 per cent gel formulationApplied immediately after irradiation
Model: Ultraviolet B irradiation (0.75 J/cm2) of the right hind paw producing a sunburn-type cutaneous burn
HC030031 0.05 per cent reversed ultraviolet B-induced mechanical and cold allodynia (maximum inhibition 69 +/- 13 per cent and 100 per cent on day 4), reduced paw oedema (77 +/- 6 per cent on day 5) and myeloperoxidase activity (69 +/- 28 per cent), and reduced irradiation-induced calcium influx.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.