Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons.
MouseOtherCD-1Male and femalen = 54 CD-1 mice in total; 37 in the maturation study and 17 in…Transcutaneous application of the light probe over the dorsal Achilles tendonContinuous-wave 980 nm and 810 nm blend (80:20 power ratio)…Dosing began 1 week after Achilles tenotomy to allow skin incisions to close
Model: Bilateral midsubstance Achilles tenotomy without repair (healing study); uninjured postnatal growth (maturation study)
Photobiomodulation did not alter collagen alignment, cell number or nuclear shape during maturation or healing and did not change maturation mechanics at either irradiance. During healing the effects on mechanics were sex-dependent, with greater stiffness and Young's modulus in treated females and…
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