HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats.
RatIschaemia-reperfusionIntestinal / mesentericSprague-DawleyMale
Model: Intestinal ischaemia/reperfusion with 6 hours of reperfusion, causing remote acute liver injury
Intestinal ischaemia/reperfusion caused hepatocyte necroptosis and remote liver dysfunction. Necrostatin-1 and HMGB1 neutralisation or inhibition reduced HMGB1 cytoplasmic translocation, hepatocyte necroptosis, tissue inflammation and M1 polarisation of Kupffer cells and circulating macrophages, pa…
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