Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.

Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.

Model: Lipopolysaccharide-induced acute lung injury, with additional LPS-induced septic death and high-fat diet obesity models and cultured cardiomyocytes and macrophages

Arachidonic acid bound MD2, prevented saturated fatty acid and lipopolysaccharide-induced TLR4 activation, reduced proinflammatory cytokine induction and septic death in mice, and prevented MD2/TLR4 dimerisation, inflammatory factor induction and tissue injury in the acute lung injury and high-fat…

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