Biguanide-Derived Polymeric Nanoparticles Kill MRSA Biofilm and Suppress Infection.
MouseWoundBALB/c and C57BL/6Male and femaleApplication to the infected wound; intravenous injection for toxicity assessment8 to 32 ug/mL in vitro; 10 mg/kg intravenously in the acute…
Model: Murine excisional skin wound infected with methicillin-resistant Staphylococcus aureus USA300 biofilm
FTP nanoparticles reduced biofilm bacterial counts by about 100-fold more than polymetformin in vitro and achieved a 1.8 log reduction of biofilm-associated MRSA USA300 in the murine excisional wound, outperforming vancomycin (0.8 log reduction), with lower cytotoxicity than polymetformin and no ac…
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