Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
Model: Severe acute pancreatitis induced by pressure-controlled retrograde infusion of 5% sodium taurocholate into the biliopancreatic duct (0.13 mL/100 g body weight at 12 mL/h), producing associated myocardial injury. A secondary experiment used mild acute pancreatitis induced by six hourly intraperitoneal injections of cerulein at 20 micrograms/kg, followed by intraperitoneal injection of 8 mL pancreatitis-associated ascitic fluid with or without anti-HMGB1 neutralising antibody at 50, 100 or 200 micrograms.
Abdominal paracentesis drainage started immediately after induction preserved myocardial architecture, lowered the cardiac histology score and oedema index, and significantly reduced serum creatine kinase-MB, cardiac troponin I and lactate dehydrogenase. Ejection fraction, fractional shortening, he…
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